Best Flea Treatment for Dogs Comparison

Dogs are like family to many people; they are our fur babies. It’s natural to want to protect them from discomfort and ailments that come from pests like fleas and ticks.

The best news is there are many dog flea treatment options that keep pests at bay. These flea medications come in various forms.

This post discusses the best flea treatments for dogs, and it will also provide a buying guide and flea treatment comparison chart that will help you in picking the best flea medication your pet needs.

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Our Top 10 Flea Treatment Comparison Chart

Flea Treatment Protects Against Usage Active Ingredient(s) Duration to Take Effect Can Start Using Protection Length Price
Advantage II for Dogs Fleas, Lice, Flea Eggs, Larvae Topical Imidacloprid and Pyriproxyfen 12 hours to kill fleas, flea eggs, larvae and lice 7 weeks or older 1 month Check Price
Frontline plus for Dogs Fleas, Ticks, Lice, Flea Eggs, Larvae Topical Fipronil, Methoprene 12 hours 8 weeks or older 1 month Check Price
Seresto Collar Fleas, Ticks, Lice Collar Imidacloprid, Flumethrin 24 hours 7 weeks or older Up to 8 months Check Price
Vet’s Best Flea Spray Fleas, Ticks, Flea Eggs Spray Clove, Peppermint, Sodium Lauryl Sulfate Instant 12 weeks or older As needed Check Price
Nexgard Chewables Flea and Ticks Chewable Afoxolaner, Naphthalene Fleas in 8 hours, Ticks in 48 hours 8 weeks Every month Prescription*
Capstar Flea Control Fleas Oral Pill Nitenpyram Kills fleas within 30 minutes, Kills 90% of fleas after 4 hours 4 weeks and older Can be taken daily Check Price
Simparica Chewables Fleas, Ticks Chewable Sarolaner Starts working after 60 minutes 6 months and older Can be taken every 35 days Prescription*
K9 Advantix II Fleas, Ticks, Flea Eggs, Larvae, Repels Mosquitos & Biting Flies Topical Imidacloprid, Permethrin, Pyriproxyfen 12 hours 8 weeks 1 month Check Price
Revolution Fleas, Ear mites Topical Selamecrin Kills 98% of fleas and ticks after 36 hours 6 weeks 1 month Prescription*
Bravecto Fleas, Ticks Chewable Fluralaner Starts killing fleas, ticks in 2 hours, Kills almost 100% after 12 hours Over 8 weeks Can be used every 12 weeks Prescription*

Best Flea Treatments

Types of Flea Treatments for Dogs

There are three types of dog flea medications available in the market. Some medications take care of worms and fleas while others take care of fleas and ticks or both combined.

By knowing the various types of drugs, you will be able to know the one you need specifically for your fur baby. These are:

Flea Pills for Dogs

Some flea pills are orally administered, and they need a prescription from a vet. They might also have some side effects. When you buy an oral prescription drug for your dog, you must be targeting flea eggs or adult eggs but never both.

Therefore, you will need to buy several drugs so that you can eradicate whatever infestation, i.e. flea or tick. Currently, there is no oral eradication for ticks. Flea pills for dogs have been proven to be the most effective to flea problems with some of them killing the fleas within hours.

Some of the more well-known pill brands on the market are Capstar and Credelio. These two brands will need a prescription from your dog’s veterinarian to get this.


  • Not only will the pill work with fleas but it can also protect your dog from ticks and conditions such as heartworm.
  • Fast acting starts working when absorbed into the dogs bloodstream.


  • Your dog will need a perscription for most oral tablets.
  • These tablets can get more expensive than other types of flea medication.

Topical Tick and Flea Medication

Such medications just like shampoo and spot-on treatments eliminate the fleas up to a certain degree. Some shampoos will kill fleas within 24 hours of use while some flea powders will take up to one week of consistent use for any result to show.

Both the shampoo and the flea powders work best when used alongside other options like flea pills.

Topical flea treatments are not only effective for destroying fleas, but they also destroy other parasites. They destroy eggs, larvae, and adult fleas.

Some popular topical fleas treatments you may have heard of are Advantage II, Frontline Plus, K9 Advantix II, and Revolution.


  • Very straightforward easy to apply.
  • Affordable.
  • usually only need to be applied once a month.


  • You need to wait for the solution to absorb/dry into your dogs skin before you can pet it.
  • Don’t let your dog lick the medicine off of itself.

Flea and Tick Dog Collars

Flea dog collars are the best flea treatment for dogs and they work by preventing tick and flea infestations. Other than being preventive, there are some that treat flea and tick infestations.

They do so by getting rid of the pests and their eggs through a chemical that’s released on the dog’s skin. These collars can last up to 8 months.

Your dog wears the collar around the neck, and it will prevent and treat infestations around the face. They can also be used alongside other flea medication options for better results.

One of the most popular flea collars is the one made by Seresto. We actually have a full article explaining how the Seresto collar works.


  • Less expensive than other flea treatments on the market.
  • Water resistant meaning your dog can wear the collar and still take baths or get wet without ruining the effectiveness.


  • It is much harder for the collar to work throughout your dog’s entire body since it is cenetalized around your dogs neck.

Flea Spray

Flea spray is quite interesting because it can actually be sprayed on your dog and even furniture, beddings, clothes, and so much more.

There are a variety of flea sprays out on the market designed to get rid of fleas lurking on your dog skin. Not all are made with the same ingredients, but some are actually made with all-natural ingredients that are more pet friendly than chemicals.

Usually, people use a flea spray along with some sort of flea medication to help prevent fleas from jumping onto your dog. This spray usually works quickly to kill the fleas on contact.


  • Very Affordable way of killing fleas.
  • Plant-based non-toxic ingredients that is safe to use all over the house and your dog.


  • Will need to work along some sort of flea medication to get the best results for your dog.

Best Flea Treatment For Dogs

10 Best Flea Treatments for Dogs

1. Advantage II for Dogs

Advantage II for dogs is an over-the-counter drug used once per month and it helps in eliminating fleas your dog. It might not work for all dogs and it cannot be used to keep ticks away.


  • Topical ointment used on the dogs skin.
  • Starts to kill fleas, flea eggs, larvae, and lice after twelve hours.
  • Works one month at a time.
  • Affordable price.
  • Made by the Bayer company.

It’s however very effective and it has few or no side effects. This drug comes in a single dose of one tube. You apply the ointment three or four times along your dog’s back if your dog is large.

As for small dogs, the ointment is applied to their shoulder blades. The drug should also not be used on cats, and you should keep it away from children.

2. Frontline Plus Flea Control for Dogs and Cats

Frontline plus flea control is a tropical treatment used for keeping fleas away; ranging from eggs, larvae, and adult fleas. It’s safe for dogs because it does not have any side effects.


  • Kills adult fleas, flea eggs, larvae, lice and ticks.
  • Used once a month
  • They have a product for any size dog from small to extra large.
  • Starts working twelve hours after applied.
  • Tpoical application to the dogs back.
  • Affordable price point.

The drug is super effective and it has an ability to kill all the fleas in a span of 12 hours or even less. One of its ingredients is S-methoprene which is an insect growth regulator that kills flea eggs and larvae.

When applied to your dog, it gives it a month’s protection from fleas while aiding in controlling sarcoptic mange infection.

The only disadvantage with this drug is that it might react with your dog’s skin. So, apply on a small part on your dog’s skin, then observe it for any reactions.

Check the flea treatment comparison chart above to see more reasons why Frontline is such a great product to use.

3. Seresto Flea and Tick Collar for Cats and Dogs

This is one of the most effective ways of keeping fleas and ticks away from your dog. The best thing about this collar is that it’s easy to use and offers your pet up to 8 months protection from fleas and ticks.


  • This is a collar application.
  • Works to kill fleas, ticks, and lice and prevent more from jumping onto your dog.
  • Water resistant collar will not make it stop working if it gets wet.
  • Affordable prices and can switched out monthly.
  • You should start seeing dead fleas after 24 hours.

The pesticides used in the collar are imidacloprid and flumethrin. They give dual action against ticks and fleas. The collar releases these two ingredients in small doses that ensure a controlled and a safe barrier for your dog or cat.

The Seresto collar works by repelling the ticks even before they bite and killing the fleas that already exist. This collar can be worn together with your pet’s collar, and it’s adjustable to suit/fit any pet. Read the Seresto collar review.

4. Vet’s Best Flea and Tick Home Spray Review

A flea spray is a wonderful product to use because it can help kill fleas on your dog and also in your home. Once the fleas have been killed on your dog, you don’t want a bunch to jump right about on your dog from the carpet.


  • Spray application.
  • Can be sprayed on your dog as well as furniture, clothing, blankets, capeting, etc.
  • Plant-based formula makes it safe and non-chemically for your dog.
  • Affordable price.
  • Can be used with other flea medications.

With the Vet’s best flea spray you can easily kill fleas that may be hiding inside of your carpets or on your dog’s bed. The spay is made up of a plant-based formula which is naturally safer for your dog then harsh chemicals.

The plant-based formula is made of clove and peppermint extracts that are naturally known to fight off pests. These ingredients do the job safely. It is perfect for dogs that may have sensitive skin as this is this gentle and natural compared to chemicals.

This is also a very affordable option. You could use this along with an existing flea medication, and it can also be used for your home. This product is usable for dogs twelve weeks and older.

5. Nexgard Chewables

The makers of Frontline that offer awesome protection against ticks and fleas, came up with this new drug. It works well to keep fleas and ticks away.

This is the first drug of its kind, and it’s in a beef-flavored chew that helps in protecting your pet for up to one month. It’s mostly recommended for pets that are less than fourteen weeks.


  • Kills fleas and ticks.
  • Beff flavored chewable makes your dog think its eating a treat.
  • Can be used on gods older than eight weeks old and larger than four pounds.
  • Approved by veternarians. ( You need a prescription to get thins for your dog)
  • Can be used monthly and typically comes in a three month supply.

It can be taken together with worm medication. You do not have to worry about its effectiveness will be washed off during baths or swimming sessions.

NexGard is known for killing three types of ticks, and these include the black-legged tick, the Lone Star, and the American dog tick.

You need to have a prescription from your pet’s vet.

6. Capstar Flea Control for Cats and Dogs

Capstar flea control for dogs and cats is an effective protection. It works after thirty minutes of application. These are flavor free tablets that can be fed directly to your dog or mixed with your dog’s food.


  • Fast working formula kills fleas thirty minutes to an hour after taking.
  • In an oral tablet form.
  • Kills 90% of fleas after four hours.
  • Comes with six tablets that can be taken per day if need be but you can likely wait until your dog develops more fleas.
  • Affordable price point.

There are formulations for dogs and there are formulations for cats. Also, when buying these formulations, make sure you get the right one for your dog since they are designed according to dog sizes.

Capstar tablets can be used for nursing or pregnant dogs, and they can be taken daily. One tablet per day.

7. Simparica Chewables

The Simparica chewable’s are a fast acting flea medications for dogs. They kill fleas within 60 minutes of administration. Its effectiveness can last up to one month.


  • This is a chewable flea medication.
  • Starts working sixty minutes after your dog ingests it.
  • Works to kill fleas and ticks fast with the fast acting formula.
  • Puppies need to be six months or older before using.

These chewable’s are ideal for preventing and killing fleas as well as keeping tick infestations (American dog ticks, brown dog tick, Gulf Coast tick, and the lone star tick) at bay.

It is an effective tick and flea medication for dogs. It is most effective if administered for one year without interruption. This medicine requires a vet’s prescription though.

8. K9 Advantix II

K9 Advantix is one of the best flea treatment in the market. It is manufactured by the same company that makes the Advantage II. It contains the same ingredients but with an additional ingredient known as permethrin that kills fleas and mosquitoes.


  • Kills fleas, flea eggs, larvae, lice, and ticks.
  • Repels mosquitos and biting flies.
  • Used once a month.
  • Easy to squeeze topical application.
  • Very affordable price point.

Permethrin is toxic to cats which means this drug should never be used on cats. The only downside about this drug is that it can cause irritation on dogs, although such cases are minimal. Read the full Frontline vs Advantix review.

9. Revolution

The Revolution drug protects your dog from fleas, heartworms, and ear mites. Revolution also protects your dogs against the sarcoptic mage, roundworms, and hookworms in cats.


  • Comes in a topical form to put on your dogs back.
  • Does require a perscription from a veternarian.
  • Protects your dog from fleas, ticks, ear mites, and heartworm.
  • Can be used on puppies older than 8 weeks of age.

However, you need to get a prescription from a vet and it should be administered only once per month. Revolution contains an active ingredient- selamactin. The ingredient penetrates the skin and enters the bloodstream thus working from inside out when treating your dogs from pests.

Revolution is also safe for use in pregnant and lactating pets. However, it should not be used for pets that are either sick or underweight since the pets might suffer from side effects like digestive disturbances.

It should not be used on puppies that are less than six weeks or kittens that are less than 8 weeks.

10. Bravecto

Bravecto is one of the best flea treatment drugs. It administered orally to prevent tick and flea prevention on your dog for up to 3 months.


  • Protects your dog for up to 12 weeks at a time.
  • Kills fleas, ticks, and even the dreaded lone star tick.
  • This is a chewable that your dog will take by mouth.
  • Can be used on puppies eight weeks and older.

One chewable tablet starts to kill pests within two hours and it provides an even longer prevention. Bravecto can be used to control the black legged tick, the American dog tick, and the lone star tick.

It’s more effective as compared to other tick/flea medications. However, it requires a prescription from a vet, and it is ideal for both puppies and adult dogs.

Dog Flea Medication

How To Choose the Best Flea Medication For Your Dog

Works Reliably and Quickly

Before you buy a flea medication, make sure you get all the details that you ought to know like how effective it is and how long it takes for it to be effective.

No one wants to pay for something that might not work as it should. 

Some brands start working two to four hours after your dog has taken it, and some can take up to twelve hours to show signs that its working.

When you look at our flea treatment comparison chart look and see how long it will take to start being effective. 

Kills all Eggs, Larvae, and Adult Fleas

If you are using medication that treats adult fleas only, then you might need to treat your dog regularly.

It is good to use medication that clears fleas at all their life-cycle stages to be on the safe side.

If there is no medication with such effects, then it is better to combine medications that will work effectively. You also need to treat your dog’s beddings and the rest of the house for better results.

Most of the topical medicines work to stop the flea life cycles, which proves to be a very effective method in eradicating the fleas.

Causeing Few or No Side Effects

It might be normal for medications to have side effects, but it is better to choose the one that has fewer side effects.

The below factors might affect the flea medication directly. However, keeping them in mind will help you in getting the best medication for your dog.

Talking to Your Vet

Your vet being a professional, is able to give you the best advice/recommendations on what will work best on your pup.

Especially if your dog is old, sick, pregnant, or lactating, besides, not all medications are good for puppies or kittens.

Checking Your Dog’s Weight

Most pet medications are packed according to the pet’s weight. Therefore, it is important to ensure that you have the right weight for your dog to enable you to get the right medication for them.

Check out the products about in the flea treatment comparison to see how they package their medicine and if you can find the right weighted product for your small or big dog.

Reading the Instructions

It is always good to read instructions and see the directions for the application before you buy the package. It is also advised to read instructions on medications that you have used in the past.

Some brands might have changed the instructions. Also, be careful not to use medications meant for cats on dogs and vice versa as it might turn fatal.

Some flea medications have ingredients in them that are actually extremely harmful and toxic to cats. It is very important to be aware of those if you have a cat in your home.

Dog Bones

Final Thoughts

Everything you need to know about flea medication for your dogs has been stated clearly. The most important thing when choosing the best flea and tick medicine for dogs is knowing its effectiveness.

The above recommendations are capable of treating and keeping fleas and ticks at bay. We hope that the flea and tick medication reviews will be of great help to you and your pup.

The flea treatment comparison chart was designed to make it easier for you to scan through to find exactly what you are looking for in a flea medication. Which brands have you used? How did they work for your dog? We would love to chat about your experience.

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